Differences in native T1 and native T2 mapping between patients on hemodialysis and control subjects

Purpose Myocardial native T1 is a potential measure of myocardial fibrosis, but concerns remain over the influence edema to increased signal in subjects prone fluid overload. This study describes differences T2 (typically raised states edema) and times patients on hemodialysis by comparing between an asymptomatic control group. Reproducibility these sequences was tested. Methods Subjects were recruited prospectively underwent 3 T-cardiac MRI with acquisition maps. Between group maps assessed using one-way ANOVAs. 30 test-retest scans within week their original scan define sequence reproducibility. Results 261 completed (hemodialysis n = 124, 137). Native significantly compared (1259 ms ± 51 vs 1212 37, p < 0.01). There no difference (39.5 2.5 39.5 2.3, 0.9). These unchanged after adjustment for relevant baseline (age, sex hemoglobin). Inter-study reproducibility mapping excellent (coefficient variability 0.9 % 2.6 respectively). Conclusions The demonstrated occurs independently two parameters are not orthogonal. Elevated may be driven water related fibrosis rather than from volume